| 摘要 |
<p>Fluorenecarboxamides were alkylated by acrylonitrile to yield amides I(R and R independently are H, alkyl, F, Cl; R2 and R3 independently are H, alkyl). Thus, 9-fluorenecarboxamide was treated with acrylonitrile in dioxane contg. PhCH2N+Me3OH- to give I(R=R1=R2=R3=H), and a mixt. of the latter and Me2CHNH2 was hydrogenated over Pt oxide to give amino amide II, which exhibited antiarrhythmic activity.</p> |
