| 摘要 |
21-Hydroxycorticosteroid esters which can have good solution stability and are therefore suitable for formulation into aqueous compositions for injection or infusion, have the formula… St-O-CO-Y-(CH2)n-X-CH2)m-SO3H… wherein St is the corticosteroid without its 21-hydroxyl group;… Y is a bond or -O-;… X is -CO-NR-,-NR-CO-, -O-,-S-,-SO- or -SO2-and R is H or C1-4 alkyl;… n is an integer of from 2 to 9, but is not 2 when X is -CO-NH- or -NH-CO; and… m is an integer of from 1 to 5, with the proviso that the sum of m and n is not greater than 10;… or a salt thereof. |
