| 摘要 |
<p>Compounds of general structural formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="34" wi="48" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein Q is:
<Chemistry id="chema02" num="0002"><Image id="ia02" he="21" wi="73" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>or pharmaceutically acceptable salts, C<Sub>1-3</Sub> alkyl esters or α-monoglyceride when Q is a dihydroxy acid wherein
<UnorderedLists id="ula01" listStyle="none"><ListItem>R<Sup>2</Sup> is hydrogen or methyl;</ListItem><ListItem>Ris
<UnorderedLists id="ula02" listStyle="none"><ListItem>(1) C<Sub>1-10</Sub>alkyl,</ListItem><ListItem>(2) C3-6cycloalkyl,</ListItem><ListItem>(3) C<Sub>2</Sub>-<Sub>lo</Sub>alkenyl,</ListItem><ListItem>(4) halo-C<Sub>1-10</Sub>alkyl,</ListItem><ListItem>(5) phenyl,</ListItem><ListItem>(6) phenyl substituted by one or more of halo, C<Sub>1-3</Sub> alkyl, or C<Sub>1-3</Sub> alkoxy,</ListItem><ListItem>(7) phenyl-C<Sub>1-3</Sub>alkyl, or</ListItem><ListItem>(8) phenyl-C<Sub>1-3</Sub> alkyl wherein the phenyl group is substituted by one or more of halo, C<Sub>1</Sub>-<Sub>3</Sub> alkyl, or C<Sub>1-3</Sub> alkoxy;</ListItem></UnorderedLists></ListItem><ListItem>R<Sup>1</Sup> is
<UnorderedLists id="ula03" listStyle="none"><ListItem>(1) hydrogen,</ListItem><ListItem>(2) C<Sub>1-3</Sub>alkyl,</ListItem><ListItem>(3) C<Sub>3-6</Sub> cycloalkyl,</ListItem><ListItem>(4) C<Sub>2-5</Sub> alkenyl,</ListItem><ListItem>(5) halo-C<Sub>1-3</Sub> alkyl,</ListItem><ListItem>(6) benzyl, or</ListItem><ListItem>(7) benzyl substituted by one or more of halo, C<Sub>1-3</Sub> alkyl or C<Sub>1-3</Sub> alkoxy; and</ListItem></UnorderedLists>
the dotted lines or circles represent all the possible oxidation and reduction states of the bicyclic system. Those compounds are useful as antihypercholesterolemic agents for the treatment of atherosclerosis, familial hypercholesterolemia, hyperlipemia and like diseases. They also have useful antifungal activity.</ListItem></UnorderedLists></p> |
