Aspartame synthesis

摘要

A method for the preparation of alpha -L-aspartyl-L-phenylalanine methyl ester (aspartame) comprises condensing a fully protected L- aspartic acid derivative with L- phenylalanine methyl ester in the presence of a condensing agent obtained from the reaction between a nitrogen-containing heterocyclic compound and an organic and inorganic acid chloride and removing the protecting groups by hydrogenation with a hydrogen donor other than molecular hydrogen in the presence of an acid.