发明名称 PROSTAGLANDINS
摘要 Novel compounds have a formula (I) …<CHEM>… wherein …<CHEM>… represents a bicyclo [2,2,1] hept-2Z-ene, bicyclo [2,2,1] heptane, 7-oxa-bicyclo [2,2,1] hept-2Z-ene, 7-oxa-bicyclo [2,2,1] heptane, bicyclo [2,2,2] oct-2Z-ene or bicyclo [2,2,2] octane substituted at the 5-position by the group R<1> and at the 6-position by the group ANR<2>R, a 6,6-dimethyl-bicyclo [3,1,1] heptane substituted at the 2-position by the group R<1> and at the 3-position by the group ANR<2>R or at the 2-position by the group ANR<2>R and at the 3-position by the group R<1>, a cyclohex-1-ene or cyclohexane substituted at the 4-position by the group R<1> and at the 5-position by the group ANR<2>R or a 1-hydroxycyclopentane substituted at the 2-position by the group R<1> and at the 2-position by the group ANR<2>R, R<1> is a 6-carboxyhex-2-enyl group or a modification thereof as defined herein; A is an unbranched or branched aliphatic hydrocarbon group with a chain length between the points of attachment to the divalent cyclic group and to the group NR<2>R of 1 to 5 carbon atoms or such a group substituted by an aromatic group; R<2> is hydrogen, an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by an aromatic group or groups, and R is a group -CO.NR<3>R<4>, -CS.NR<3>R<4>, -CNH.NR<3>R<4>, -CO.R<4> or -CS.R<4> in which R<3> is hydrogen, an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by an aromatic group or groups, and R<4> is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted directly by an aromatic.
申请公布号 ZA8209222(B) 申请公布日期 1984.07.25
申请号 ZA19820009222 申请日期 1982.12.15
申请人 NAT RES DEV 发明人 JONES ROBERT LESLIE;NORMAN HAPPER WILSON
分类号 C07C59/74;A61K31/16;A61K31/17;A61K31/195;A61K31/215;A61K31/557;A61P7/02;A61P11/08;A61P29/00;C07C43/315;C07C45/44;C07C51/00;C07C59/325;C07C59/353;C07C59/62;C07C59/80;C07C59/86;C07C67/00;C07C69/608;C07C69/716;C07C69/738;C07C229/28;C07C229/32;C07C231/00;C07C233/05;C07C233/65;C07C235/06;C07C235/20;C07C235/46;C07C237/24;C07C239/00;C07C275/26;C07C275/28;C07C335/16;C07C401/00;C07C405/00;C07D213/55;C07D277/62;C07D307/00;C07D493/00;C07D493/08 主分类号 C07C59/74
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