| 摘要 |
<p>PURPOSE:To obtain the titled compound useful as a remedy for the diseases of the circulatory organs, in high yield, by selectively reducing a DELTA<2>, DELTA<7>-prostaglandin E1 compound, and if necessary, subjecting the product to the removal of protecting group and/or hydrolysis. CONSTITUTION:The objective compound which is the compound of formula II, its 15-epimer, their enantiomers, or their mixture at arbitrary ratio can be prepared by selectively reducing a DELTA<2>, DELTA<7>-prostaglandin E1 which is a compound of formula I (R<1> is H or 1-10C alkyl; R<2> and R<3> are H, tri-(1-7C)silyl, 2-7C acyl, etc.; R<4> is 1-10C alkyl or 5-7C cycloalkyl), its 15-epimer, their enantiomers, or their mixture at arbitrary ratio, with e.g. a zinc-based reducing agent (e.g. zinc dust), and if necessary subjecting the product to the removal of protecting groups and/or hydrolysis. The compound of formula I can be prepared by removing OH group from the compound of formula III (R<21> and R<31> are R<2> and R<3> except H).</p> |
