| 摘要 |
<p>Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: X is CH2, O, S, or NR where R is C1-4 alkyl; R1 and R2 are independently selected from hydrogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, halogen or CF3; R3 is C1-7 alkyl, C2-5 alkynyl, C3-7 cycloalkyl, C4-7 cycloalkenyl or C1-6 alkyl substituted by C2-7 alkenyl, C2-7alkynyl, C3-7 cycloalkyl, hydroxy, thiol, C1-6 alkoxy, C1-6 alkylthio, carboxy, C1-6 alkoxycarbonyl, C2-7 alkanoyl, amino optionally substituted by one or two C1-4 alkyl or by C4-6 polymethylene optionally containing an oxygen or nitrogen atom, aminocarbonyl optionally N-substituted by one or two C1-6 alkyl groups, or benzoyl or phenyl either being optionally ring-substituted by one or two C1-4 alkyl, C1-4 alkoxy, halogen or trifluoromethyl; and one of R4, R5 and R6 is C1-6 alkyl and the other two are independently hydrogen or C1-6 alkyl, having anti-depressant and/or anxiolytic activity, a process for their preparation and their use. </p> |
