| 摘要 |
PURPOSE:To prepare the titled compound useful as a synthetic intermediate of pharmaceuticals, in a short time, in high yield, by reacting p-toluenesulfonyl halide with (meth)allyl alcohol in toluene at a specific temperature. CONSTITUTION:The objective compound is prepared by reacting p-toluenesulfonyl halide with (meth)allyl alcohol in toluene in the presence of a quaternary ammonium salt (e.g. benzyltriethylammonium chloride) and an alkali (e.g. sodium hydroxide) at <=15 deg.C, preferably 5-15 deg.C, especially 5-10 deg.C for 1hr. The amounts of (meth)allyl alcohol, the quaternary ammonium salt, the alkali and toluene are 1.1-1.3moles, 0.03-0.1mole, 1.2-1.5moles and 3-6moles per 1mole of p-toluenesulfonyl halide, respectively. |
