| 摘要 |
Title compds. (I; A = a, b, c; R5 = H, CF3, halogen; R6 = H, CF3, halogen, lower alkyl; R1 = cyano, lower alkanoyl,-COOR4; R3 = lower alkyl; D = >C=0, X=S) were prepd. from II. Thus, 110 g 3,4-dihydro-4-(2,4-dimethoxybenzyl)-2H-1,4-benzoidazepin-2,5(1H)-dione and 330 ml anhyd. DMF were treated with 45.74 g potassium tert-butylate, and cooled to -30oC, followed by addition of 61 g diethyl chlorophosphat at -20-30oC for 20 min. The reaction product was stirred at -20oC for 10 min to give I.
|
