| 摘要 |
<p>1. Carboxamide compounds of the formula …<CHEM>… and their pharmaceutically-acceptable salts;… wherein R<1> is hydrogen, alkyl having 1 to 4 carbon atoms or a group of the formula -CH2-CH2-NR<3>R<4> wherein R<3> and R<4> are each alkyl having 1 to 3 carbon atoms;… R<2> is alkyl having 8 to 15 carbon atoms or cyclo-alkyl having from 6 to 12 carbon atoms;… and Q is …<CHEM>… wherein R<5> and R<6> are each hydrogen or methyl;… with the proviso that when Q is …<CHEM>… the two groups attached to the …<CHEM>… group have a trans relationship to each other, pharmaceutical compositions containing them, processes for their preparation, and intermediates useful therein. The compounds of the formula (I) are SRS-A antagonists useful in such disease states as allergic rhinitis, certain skin disorders, and allergic bronchial asthma.</p> |
