Radiolabelled metallocene derivatives.

摘要

The invention relates to radiolabelled metallocene derivatives of the general formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="14" wi="49" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein Me is a metallocenyl group with a radioactive central atom,
<UnorderedLists id="ula01" listStyle="none"><ListItem>R is a carbonyl or methylene group,</ListItem><ListItem>R, is a hydrogen atom or an alkyl group having 1-4 carbon atoms,</ListItem><ListItem>A is a carboxy group or a pharmaceutically acceptable salt thereof, or an alkoxycarbonyl or alkanoyl group having 2-5 carbon atoms, and</ListItem><ListItem>n is 1 - 4.</ListItem></UnorderedLists>

The invention also relates to radiodiagnostic compositions comprising said radiolabelled metallocene derivatives and to a method of performing a radiodiagnostic examination, in particular of examining the renal function.