| 摘要 |
Compounds having the formula: <CHEM> wherein R<4> is hydrogen or chloro; R<5> is carboxy, an ester thereof, or tetrazolyl; R<2> is hydrogen, halo, or alkoxy of 1 to 4 carbon atoms; and R<3> is hydrogen or bromo, with the proviso that when R<4> is hydrogen, R<5> is carboxy and R<2> or R<3> is other than hydrogen; and that when R<4>, R<2> and R<3> are all hydrogen, R<5> is tetrazolyl; the stereoisomers thereof and the pharmaceutically acceptable salts thereof. The compounds of formula B wherein R<5> is carboxy or tetrazolyl have pharmaceutical utility eg. as antiinflammatory agents. The compounds where R<5> is a carboxylic ester are intermediates for the corresponding acids. Pharmaceutical composition containing the active compounds are also disclosed. |
