| 摘要 |
NEW MATERIAL:The compound of formula I [R<1> is alpha,beta or gamma-amino acid residue (ester bond) which may have lower alkyl group substituted to the amino group; R<2> is 1-alkanoyloxyalkyl, 1-alkoxycarbonyloxyalkyl, phthalidyl, etc.; R<3> is carbamoyloxymethyl, etc. which may be substituted with lower alkyl; R<4> is H or OH] and its salt. EXAMPLE:(5-Methyl-1,3-dioxolen-2-on-4-ylmethyl) 7-[D-O-(L-alanyl)-mandelamido]- 3-[(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl]-3-cephem-4-carboxylate hydrochloride. USE:Preventive and remedy for microbism. PROCESS:The objective compound can be prepared by reacting the compound of formula II (or its reactive derivative) with the compound of formula III. |
