发明名称 |
Use of 8-substituted guanine derivatives in the manufacture of a medicament. |
摘要 |
<p>Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functionality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.</p> |
申请公布号 |
EP0112632(A2) |
申请公布日期 |
1984.07.04 |
申请号 |
EP19830306791 |
申请日期 |
1983.11.08 |
申请人 |
SCRIPPS CLINIC AND RESEARCH FOUNDATION |
发明人 |
GOODMAN, MICHAEL G.;WEIGLE, WILLIAM O. |
分类号 |
C07H19/16;(IPC1-7):61K31/70 |
主分类号 |
C07H19/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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