| 摘要 |
The production of a 1- beta -D-ribofuranosyl-1,2,4-triazole of the formula <IMAGE> wherein R is hydroxy, amino, or alkoxy, is carried out by reacting a 1,2,4 triazole of formula <IMAGE> wherein R is hydroxy, amino, or alkoxy group, with a greater than equimolar amount of a ribofuranosyl group donor in the presence of a nucleoside phosphorylase preparation at a temperature in the range from 40 DEG to 65 DEG C. for more than 10 minutes, and recovering a 1- beta -D-ribofuranosyl-1,2,4-triazole from the reaction solution. The temperature is preferably from 55 DEG to 65 DEG C. and the time is preferably 10 minutes to 20 hours. An elevated temperature higher than the usual enzyme reaction temperature isused to prevent undesirable enzymatic reactions.
|
