PROCESS FOR THE PREPARATION OF CYCLIC CARBOXYLIC ACID DERIVATIVE

摘要

Title compds. (I; R = C1-4 alkyl, C1-4 alkoxy, Ph; B = carboxyl group), useful as analgesics, antiinflammatories and antipyretics, were prepd. from II(A = cyano, carbamoyl). Thus, 3 g l-cyano-4-benzoylindan was refluxed at N2 gas in the mixed soln. of 54 ml H2O and 45 ml conc. H2SO4 for 3.5 hr, and cooled, extracted by ether to give 4-benzoylindan-1-carboxylic acid.