IMPROVEMENTS IN OR RELATING TO A PROCESS FOR PRODUCING BETA-LACTAM COMPOUNDS

摘要

There is described a process for preparing a compound of Formula (IV): …… or an addition salt thereof, in which R is amino, a protected amino group, hydrogen, C1-C4 alkyl, C1-C4 alkoxycarbonyl, carboxy, protected carboxy, or C1-C4 alkyl substituted by hydroxy, halogen, methoxy, amino, protected amino, protected carboxy, or cyano; R<1> is hydrogen, C1-C4 alkyl, C1-C4 alkoxycarbonyl, protected carboxy, carboxy, phenyl, substituted phenyl substituted by C1-C4 alkyl, hydroxy, halogen, C1-C4 alkoxy, amino, protected amino, carboxy, protected carboxy, or cyano, or C1-C4 alkyl substituted by hydroxy, halogen, methoxy, amino, protected amino, carboxy, protected carboxy or cyano; and Z is hydrogen, an acyl group or sulfo group of the formula-SO3<->M<+> in which M<+> is an alkali metal cation or tri- or tetrasubstituted ammonium ion);… which comprises… a) ring closure of a compound of Formula (III): …… in which R,R<1> are as defined above for Formula (IV), Z is acyl or SO3<->M<+> and Y is hydroxy, bromo or chloro, to provide a compound of Formula (IV) in which Z is acyl or SO3<->M<+>; or,… b) acylating or treating with pyridine-SO3, a compound of Formula (IV) in which Z is hydrogen to produce a compound of Formula (IV) in which Z is other than hydrogen; or… c) exposing a compound of Formula (IV), in which Z is acyl other than pivaloyl to solvolytic conditions to produce a compound of Formula (IV) in which Z is hydrogen; … d) and, if desired, removing any protecting groups present and forming an addition salt thereof;… and certain compounds per se resulting therefrom.