| 摘要 |
An L-aspartyl-L-phenylalanine lower alkyl ester of which the amino group of the aspartyl residue is protected with a formyl group can be deformylated under selected conditions, i.e. in a strong acid, having a specific normality range at a specific elevated temperature range, and the splitting of the formyl group from the aspartyl moiety amino group can be effected selectively and efficiently in a short time (e.g. as short as 15 seconds to 60 minutes), while the splitting of the ester bond or the peptide bond is suppressed. The deformylation is useful in the production of alpha -L-aspartyl-L-phenylalanine methyl ester, a dipeptide sweetener. |
