| 摘要 |
<p>Compounds of the Formulas I or II (herein) wherein R is alkyl, X is 0 or CH<Sub>2</Sub>, n is an integer from 4 to 8, and Ar is phenyl or substituted phenyl, useful as antiviral agents especially against picornaviruses. Said compounds are prepared by:
<UnorderedLists id="ula01" listStyle="none"><ListItem>a) reacting an alkali metal derivative of 3-R-5-methylisoxazole with a compound of the formula Hal-(CH<Sub>2</Sub>)<Sub>n</Sub>-X-AR' where Hal is bromine or iodine, and Ar' is phenyl or phenyl substituted by one or two halogen, lower-alkyl, lower-alkoxy, nitro or cyano substituents to produce a compound of the Formula (I) wherein Ar is phenyl or phenyl substituted by one or two substituents which are halogen, lower-alkyl, lower-alkoxy, cyano or tertiary-butyloxy-carbonyl; or</ListItem><ListItem>b) reacting a compound of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="14" wi="105" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>where Hal is bromine or iodine, with an alkali metal salt of a compound of the formula
<Chemistry id="chema02" num="0002"><Image id="ia02" he="7" wi="32" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>where Ar' has the meaning given above, followed by optimal conversions of the phenyl substituents of Ar.</ListItem></UnorderedLists></p> |
