发明名称 |
Hybrid cell lines producing monoclonal antibodies directed against Haemophilus influenzae |
摘要 |
Continuous hybrid cell lines for producing monoclonal antibodies directed against outer membrane antigens of Haemophilus influenzae type b have been developed. The hybrid cell lines were established by fusing differentiated lymphoid cells primed with outer membrane antigens of Haemophilus influenzae type b with hybridoma cells. The resulting fused cells were cloned and characterized as to antibody specificity against antigenic determinants of outer membranes of Haemophilus influenzae type b. One hybrid produces a monoclonal antibody which is capable of conferring passive immunity on Hib infected hosts.
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申请公布号 |
US4455296(A) |
申请公布日期 |
1984.06.19 |
申请号 |
US19820345201 |
申请日期 |
1982.02.02 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
HANSEN, ERIC J.;KETTMAN, JOHN R.;ROBERTSON, STELLA M. |
分类号 |
A61K38/00;A61K39/00;C07K14/285;C07K16/12;(IPC1-7):A61K39/40;A61K39/39;C12N5/00;C12N15/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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