| 摘要 |
Compounds of the formula …<CHEM>… and their pharmaceutically acceptable salts, wherein:… U is oxygen, sulfur or nitrogen substituted with hydrogen or alkyl having 1-4 carbon atoms;… n is zero or one;… W is carbonyl or hydroxymethylene;… R is hydrogen or alkyl having 1-4 carbon atoms;… X is hydrogen, chloro, bromo, iodo, alkyl having 1-4 carbon atoms, dimethyl or (CH2)mQ wherein m is 1 or 2 and Q is phenyl or halophenyl, with the proviso that when X is dimethyl, n is one;… Y is hydrogen, halo, nitro, trifluoromethyl, alkoxy having 1-4 carbon atoms or alkyl having 1-4 carbon atoms; and… Z is hydrogen, halo, nitro, trifluoromethyl, alkoxy having 1-4 carbon atoms or alkyl having 1-4 carbon atoms, with the proviso that if either Y or Z is nitro the other is hydrogen. …<??>The compounds are useful in the treatment of certain chronic complications arising from diabetes mellitus, such as diabetic cataracts, retinopathy and neuropathy. |
