| 摘要 |
Compounds of the formula
<CHEM>
and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D define the chirality;
R1 is hydrogen or C1-C3 primary alkyl;
R2 is C1-C4 primary or secondary alkyl, allyl, cyclopropylmethyl, C1-C2 hydroxyalkyl, or
-(CH2)m-U-CH3 in which U is -S- or @S-O and m is 1 or 2;
R3 is hydrogen, C1-C4 primary or secondary alkyl, cyclopropylmethyl, or allyl;
X is hydrogen, halo, hydroxy, C1-C3 alkoxy, nitro, C1-C3, alkyl, or trifluoromethyl; and
Z is -CH2OR4,
-@-NHR4, or
-@-OR5,
in which R4 is hydrogen or C1-C3 alkyl and R5 is C1-C3 alkyl; are useful analgesic agents. These compounds of formula I are prepared by deblocking the corresponding blocked compound of formula I by conventional methods. |
