| 摘要 |
<p>Derivatives of aminopyridinecarboxylic acids which inhibit the dipeptidyl carboxy peptidase (DPCP), methods for their preparation and pharmaceutical compositions containing them. The compounds have formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="27" wi="87" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>where
<UnorderedLists id="ula01" listStyle="none"><ListItem>Z is hydrogen, alkyl having from 1 to 3 carbon atoms, halogen or alkoxy having from 1 to 3 carbon atoms;</ListItem><ListItem>R1 is hydrogen, alkyl having from 1 to 6 carbon atoms, arylalkyl having from 7 to 12 carbon atoms, aryl having from 6 to 15 carbon atoms;</ListItem><ListItem>m and n are an integer of from 0 to 4 each provided, however, that m + n is lower than 5;</ListItem><ListItem>R2 is hydrogen, alkyl having from 1 to 6 carbon atoms or arylalkyl having from 7 to 12 carbon atoms;</ListItem><ListItem>R3 is hydrogen or acyl having from 1 to 8 carbon atoms;</ListItem><ListItem>R4 is hydrogen or alkyl having from 1 to 3 carbon atoms;</ListItem></UnorderedLists>
and their pharmaceutically acceptable salts with organic or inorganic acids.</p> |
