| 摘要 |
NEW MATERIAL:The compound of formula I [R is morpholino or piperidino; R1 is H or 1-3C alkyl; R2 is 1-8C alkyl, cyclohexyl, (substituted) phenyl, group of formula II (R3 and R4 are H, 1-4C alkyl or together form piperidino, piperazino, etc.), group of formula III (n is 0-2; R5 is 1-10C alkyl, cyclohexyl, phenyl, etc.), etc.]. EXAMPLE:N,N-Dimethyl-alpha-(N-morpholino-N-nitrosamino)acetamide. USE:It has artery-relaxing and blood platelet coagulation suppressing activities and is useful for the prevention or remedy of various diseases caused by the formation of thrombus, e.g. as an antithrombogenetic agent, a vasodilator, etc. PROCESS:The compound of formula I can be prepared by nitrosating the compound of formula VI obtained either by reducing the condensation product of the substituted amine of formula R-NH2 and the compound of formula IV, or by condensing the compound of formula R-NH2 with the compound of formula V. |
