UN METODO PARA PREPARAR ESPIRO-(MONO- Y DIFLUOROFLUOREN-9,4-IMIDAZOLIDIN)-2,5'-DIONAS.

摘要

Inhibition of aldose reductase activity with tetracyclic spiro-hydantoins, new tetracyclic spirohydantoin derivatives useful in the treatment of complications arising from diabetes mellitus, and a process for preparing spiro-imidazolidine-diones by reacting a mono- or di-fluorofluorene with an excess of oxygen and a tetralkyl- or arylalkyl-trialkyl-ammonium hydroxide are disclosed.