摘要 |
Antiinflammatory chlorofluoropregnadienediones I (R1, R2=C1-C6 alkyl, aryl; Z=H, Me)were prepd. Thus, 20g 9β,11β-epoxy-16β-methyl-pregna-1,4-diene-17,21-diol-3,20-dione-17,21-dipropionate was refluxed with 2g p-toluene sulfonate and 200mL isoprophenylacetate for 2hrs. and treated with 10g F.C1O3 at 0≦̸C for 16hrs. to give 22g 6 -fluoro-9β,11β-epoxy-16β-methyl-pregna -1,4-diene-17,21-dione-17,21-dipropionate.
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