发明名称 |
process for the preparation of optically-active cyanomethyl esters. |
摘要 |
<p>Stereoisomerically-enriched cyanomethyl esters are prepared by treating a non-symmetrical ketene or an alphachiral carboxylic acid halide or reactive derivative thereof with an optically-active alphahydroxynitrile. Certain optically-active optionally substituted S-alphacyano-3-phenoxy-benzyl alcohol intermediates are prepared by treating the corresponding aldehyde of ketone with a source of hydrogen cyanide in the presence of a substantially water-immiscible, aprotic solvent and a cyclo(D-phenylalanyl-D-histidine) as a catalyst. </p> |
申请公布号 |
EP0109681(A2) |
申请公布日期 |
1984.05.30 |
申请号 |
EP19830111562 |
申请日期 |
1983.11.18 |
申请人 |
SHELL OIL COMPANY |
发明人 |
STOUTAMIRE, DONALD W.;TIEMAN, CHARLES H.;DONG, WALTER |
分类号 |
B01J31/02;C07B61/00;C07C45/89;C07C49/88;C07C253/00;C07C253/30;C07C255/00;C07C255/37;C07C255/38;C07C255/53;C07D403/06;C07K5/06;C07K5/078;C07K5/12 |
主分类号 |
B01J31/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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