发明名称 |
ANTI-TUMOR AGENT COMPRISING AN ORGANOSILICON COMPOUND |
摘要 |
The invention provides an anti-tumor agent evidenced to be effective in suppressing the growth of Ehrlich's cancer cells, Lewis lung cancer cells and B-16 melanoma cells both in vitro and in vivo tests, which comprises, as an effective ingredient thereof, an omega -(aminoalkylthio)alkyl trihydrocarbyl silane of the general formula R3Si-(-CH2-)m-S-(-CH2-)n-NR<1>2, in which R is a hydrogen atom or a substituted or unsubstituted hydrocarbon group having from 1 to 6 carbon atoms, R<1> is an alkyl group having from 1 to 3 carbon atoms or a hydrogen atom and m and n are each an integer from 1 to 6, or a salt form thereof such as hydrochloride or acetate: In particular, 2-(2-amino-ethylthio)ethyl trimethyl silane, which is a novel compound not reported in prior art literatures, was synthesized and tested for the anti-tumor activity. |
申请公布号 |
DE3163299(D1) |
申请公布日期 |
1984.05.30 |
申请号 |
DE19813163299 |
申请日期 |
1981.08.05 |
申请人 |
SHIN-ETSU CHEMICAL CO., LTD. |
发明人 |
TOYOSHIMA, SHIGESHI;SATO, RYUICHI;ITO, KOICHI;SHINOHARA, TOSHIO;YAMAMOTO, YASUSHI |
分类号 |
A61K31/695;A61P35/00;C07F7/08;C07F7/10;(IPC1-7):C07F7/08;A61K31/69 |
主分类号 |
A61K31/695 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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