| 摘要 |
<p>A derivative of a fibrinolytically active glycoprotein in which at least part of the carbohydrate portion of the protein is absent or has been degraded, characterised in that the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis at a rate such that the pseudo-first order rate constant for hydrolyses is in the range 10-6 sec -1 to 10-3 sec -1 in isotonic aqueous media at pH 7.4 at 34oC. The derivative is useful in treating thrombosis. </p> |
