SUBSTITUTED DIBENZO(B,F)THIEPIN-3-CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

8-Fluorodibenzo[b,f] thiepine and 8-hydroxydibenzo[b,f]-thiepin-3-carboxylic acid-5-oxide compounds of formula: where Z is thio, sulfinyl or sulfonyl; and and their pharmaceutically salts are novel. They are used in the treatment and control of allergic conditions such as allergic asthma and are made into pharmaceutical compositions for that purpose. The compounds are made by hydrolysing the corresponding 3-cyano compounds. The R(-) isomer of 8-fluorodibenzo[b,f] thiepin-3-carboxylic acid-5-oxide is particularly useful as an antiasthmatic.