PROCEDE D'ISOLATION ET DE PURIFICATION DES DERIVES D'AMINOSACCAROSES COMME INHIBTIEURS DE GLYCOSIHYDROLASES

摘要

New amino sugar derivatives of the formula wherein R is a glucose unit or an oligosaccharide chain of 2 to 7 glucose units glycosidically linked .alpha.-1:4 inhibit glycoside-hydrolases of the digestive tract. A representative embodiment is O-{4,5-bisdesoxy-4-{1 S-¢1,4,6/5)-4,5,6-tri-hydroxy-3-hydroxymethylcyclohex-2-en-1-ylamino!-.alpha.-D-gluco-pyranosyl}-(1?4)-O-.alpha.-D-glucopyranosyl-(1?4)-O-.alpha.-D-gluco-pyranosyl-(1?4)-D-glycopyranose. (R = 3 glucose units). In addition to this series of compounds, an isomeric series of amino sugars for compounds having three or more glucose units are simultaneously produced by Actinoplanacetes. The isomeric material having three glucose units is O-{4,6-bisdesoxy-4-{1 S-¢1,4,6/5)-4,5,6-dihydroxy-3-hydroxy-methyl-4-O-.alpha.-D-glycopyranosyl-(1?4)-cyclohex-2-en-1-ylamino!-.alpha.-D-glycopyranosyl}-(1?4)-O-.alpha.-D-glucopyranosyl-(1?4)-D-glucopyranose.