| 摘要 |
<p>Compounds of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="13" wi="37" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sup>1</Sup> stands for an alk-2-enyl radical of not more than 5 carbon atoms or a furylmethyl radical, R<Sup>2</Sup> stands for an alk-2-enyl or alkyl radical of not more than 5 carbon atoms or a furylmethyl radical, >N-A, B, D, E and F stand for defined amino acid or aza-amino-acid residues, and in particular one or both of B and D stand(s) for an amino acid residue of the formula -NH.C(1-3C alkyl)(1-3C alkyl).CO- or a similar residue, and X stands for -OR<Sup>7</Sup> or -NR<Sup>7</Sup>R<Sup>8</Sup>, wherein R<Sup>7</Sup> and R<Sup>8</Sup>, which may be the same or different, stand for hydrogen or a (1-4C)alkyl radical, and wherein the linkages are all conventional peptide linkages or in the case of D-E the peptide linkage is replaced by the group -CH<Sub>2</Sub>S-, and pharmaceutically-acceptable salts thereof. Processes for the manufacture of the compounds. Pharmaceutical compositions comprising one of the compounds and a pharmaceutically-acceptable diluent or carrier. The compounds are selective opiate δ-receptor antagonists.</p> |
