Process for the preparation of D(+)-biotin

摘要

The stereospecific preparation of D(+)-biotin is improved by a synthetic route involving the conversion of 3,4-isopropylidene-D-arabinose in which the OH group in the 2-position is not protected, into an ester of 6,9-dihydroxy-7,8-isopropylidenedioxynona-2,4-dienoic acid, the latter then being catalytically hydrogenated and subsequently converted into D(+)-biotin in a manner known per se.