Pyrimidine derivatives and a pharmaceutical composition containing them

摘要

New 4-anilinopyrimidine derivatives of formula (I): <IMAGE> (I) (wherein: R1 and R2 are the same or different and each represents a C1-C6 alkyl group or R1 and R2 together represent a C3-C5 alkylene group; R3 represents a hydrogen atom or a C1-C6 alkyl group; n is 0, 1 or 2; and R4 represents a C1-C6 alkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group, a halogen atom, a nitro group, a C1-C6 alkanesulphonyl group, a cyano group, a carboxy group or a C2-C7 alkoxycarbonyl group and, when n is 2, the two groups represented by R4 may be the same or different or they may together represent a methylenedioxy group) and pharmaceutically acceptable acid addition salts thereof have been found to have strong antidepressant activity, with low toxicity and very few side-effects. The compounds may be formulated in conventional pharmaceutical compositions for administration by various routes and may be prepared by reacting a 4-halopyrimidine with aniline or an aniline derivative.