| 摘要 |
Compounds of general formula (I) <IMAGE> (I) and physiologically acceptable salts and hydrates thereof in which R1 and R2 each represent methyl groups or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or hexamethylenimino group; R3 represents hydrogen or methyl; Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms; R4 represents a hydrogen atom and R5 represents a C1-4 alkyl group; or R4 and R5 together with the atoms to which they are attached form a tetrahydropyranyl ring; and either n is zero, X is oxygen, m is 3 or 4, and Q is a benzene ring linked through the 1- and 3- positions; or n is 1, X is sulphur, m is 2, and Q is a furan ring linked through the 2- and 5- positions with optionally a methyl substituent on the carbon atom adjacent to the group R1R2NCH2, or Q is a thiophene ring linked through the 2- and 4- positions with the group R1R2NCH2 in the 2- position; with the proviso that when Q is other than a benzene ring, R1 and R2 are methyl groups, are disclosed as having action as histamine H2-antagonists.
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