| 摘要 |
Imidazothienopyrimidinediones I (R1= H,C1,Br, C1-C4 alkyl; R2=H, Me) were prepd. Thus, a mixt. contg. 46.5g 1,4-dihydro-4-oxo-2-oxothieno [3,2-d pyrimidine-3(2H)-acetate Me ester, 875mL acetone, and 110g K2CO3 was treated with 45mL dimethyl sulfate and refluxed for 3hrs. to give 36g 2-methyl thio-4-oxothieno 3,2-d pyrimidine-3(4H)-acetate methyl ester. I (R1=R2=H) had an antiallergic ED50 of 32mg/kg orally in rats.
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