| 摘要 |
<p>2-Q-6-Q min -8-R-pyrido[2,3-d]pyrimidin-5(8H)-ones (I), where Q is 4 (or 3)-hydroxyphenyl, 4(or 3)-methoxyphenyl, 4 (or 3)-pyridinyl or 4(or 3)-pyridinyl having one or two lower-alkyl substituents, R min is hydrogen or alkyl having one to four carbon atoms, Q is hydrogen, amino or nitro, and R is alkyl having from one to four carbon atoms, CH(C2H5)2, (CH2)n = CHCH2 where n is 1 or 2, or Y-Z where Y is alkylene having from one to four carbon atoms and having its connecting linkages on different carbon atoms and Z is hydroxy, OR1 or NR1R2 where R1 and R2 are each methyl or ethyl, or acid-addition salts thereof and there preparation by reacting a 2-Q-4-R min -pyrido[2,3-d]pyrimidin-5(8H)-one of the Formula III (herein) where Q is 4 (or 3)-methoxyphenyl, 4(or 3)-pyridinyl or 4(or 3)-pyridinyl having one or two lower-alkyl substituents or alkali or alkaline earth metal salt thereof with an alkylating agent. Also shown is the cardiotonic use of I where Q is 4(or 3)-hydroxyphenyl, 4(or 3)-pyridinyl or 4(or 3)-pyridinyl having one or two lower-alkyl substituents and Q min is hydrogen or amino. The novel compounds of Formula III and their preparation are also claimed. </p> |
