MANUFACTURE OF AMIDE OF ALPHA- AMINOACETAMIDOPENICILLANIC ACID DERIVATIVE, ESTER OF SAME AND SALT OF SAME

摘要

Cpds. of formula (I) (where X is H or p-OH, R is H or linear or cyclo amino or (unsatd.) alkyl, aryl or alkyl-aryl, the alkyl, aryl or alkyl-aryl opt. having hetero atom), are prepd. by reacting a cpd. of formula (II) (where M is H, cation, linear or cyclic alkyl which may have hetero atom, aryl or alkyl-aryl) with a cpd. of formula (III) (wherein R' and R" are linear or cyclic alkyl, aryl or alkyl-aryl which may have hetero atom). Reaction is an organic or aq. medium at -40 to +30 deg.C and pH is regulated to separate the prod.. -