| 摘要 |
Compounds of the general formula (I) are prepared by the following route: <FORM:1087243/C2/1> The intermediates of Formula (V) may alternatively be prepared by the following route: <FORM:1087243/C2/2> Compounds (I) may be converted to acid addition and quaternary ammonium salts and the latter may be converted to different salts, e.g. via the corresponding hydroxide. In the above formulae R1 is C1- 8 alkyl, halogen, tri-fluoromethyl or C1- 8 alkylenedioxy, and when more than one R1 substituent is present these can be the same or different, x is 0-4 (provided that when R1 is alkylenedioxy, x does not represent 3 or 4), R2 is hydrogen, C1- 8 alkyl, phenyl or phenyl substituted by at least one radical selected from C1- 8 alkyl and halogen, CnH2n is a C2- 6 alkylene radical, R3 and R4 are C1- 8 alkyl or are linked together to form, with the attached nitrogen atom, a 5-7 ring atom saturated heterocyclic radical, and Hal is halogen. The compounds of the invention are antifertility agents, anti-oestrogenic agents, gonadotrophin-inhibiting agents, agents for lowering lipid and cholesterol blood levels, anti-inflammatory agents and central nervous system stimulants, and may be administered in the form of pharmaceutical or veterinary preparations containing them together with a carrier. |
