发明名称 CARDIOTONIC 4-SEMICARBAZIDE QUINDYOLINES
摘要 Compounds of the formula <IMAGE> wherein R1 is hydrogen, alkyl of 1 to 4 carbon atoms or trifluoromethyl; R2, R3 and R4 are each independently hydrogen, methyl or ethyl; R5 is hydrogen, alkyl of 1 to 8 carbon atoms, phenyl-(alkyl of 1 to 8 carbon atoms), cycloalkyl of 3 to 7 carbon atoms, (alkoxy of 1 to 4 carbon atoms) carbonyl-methyl, phenyl, substituted phenyl, naphthyl or substituted naphthyl; or R4 and R5, together with each other, are alkylene of 4 to 5 carbon atoms, optionally interrupted by -O- or -NR6-, where R6 is alkyl of 1 to 4 carbon atoms; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics.
申请公布号 AU2092083(A) 申请公布日期 1984.05.10
申请号 AU19830020920 申请日期 1983.11.02
申请人 BOEHRINGER INGELHEIM INTERNATIONAL G.M.B.H. 发明人 ERNST OTTO RENTH;ANTON MENTRUP;KURT SCHROMM;WERNER TRAUNECKER;RICHARD REICHL
分类号 A61K31/505;A61K31/517;A61P9/00;A61P9/04;A61P9/08;A61P9/12;A61P43/00;C07D239/94 主分类号 A61K31/505
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