| 摘要 |
Novel alkane derivatives of the formula (I) …<CHEM>… or a pharmaceutically acceptable salt thereof, wherein:… R1 is hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, or phenyl;… R2 is hydrogen, C1-C6 alkyl, or C2-C6 alkenyl;… R3 is hydrogen, C1-C10 alkyl, phenyl, C1-C10 alkyl-substituted phenyl, biphenyl, or benzylphenyl;… R4 is -COOR7, -CONR8R9 -CONHOH, -NR8R9, -SC(=NH)NH2, cyano, cyanothio, …<CHEM>… where R7 is hydrogen or C1-C4 alkyl,… R8 and R9 are each independently hydrogen, C1-C3 alkyl, or when taken together with the nitrogen atom form a morpholine or N-methyl piperazine ring,… R is hydrogen, C1-C4 alkyl, or -CH2COOR7, and p is 0, 1, or 2;… R5 and R6 are each independently hydrogen or C1-C3 alkyl;… and n is 0-10 are leukotriene antagonists. |
