摘要 |
PURPOSE:The titled pharmaceutical preparation useful as a remedy for pectic ulcer preventing disappearance of adhesivity in an artificial gastric juice, obtained by adding an amino acid containing neither benzene ring nor sulfur atom in the structure to sucralfate. CONSTITUTION:A pharmaceutical preparation of sucralfate obtained by adding an amino acid (e.g., glycine, alanine) containing neither benzene ring nor sulfur atom in the structure to sucralfate. Sucralfate (aluminum salt of sucrose sulfuric acid ester) is an improved remedy for ulcer having low side effect, has an antipepcin activating action, especially when it is administered orally, it becomes an adhesive paste with an acid in the stomach, bonded to an ulcer site, and shows a protecting action on mucosa durably, however, this adhesivity in an artificial gastric juice is reduced in an aqueous suspension or a solid pharmaceutical preparation of it under highly humid conditions at high temperature. The addition of the amino acid provides the stable pharmaceutical preparation having adhesivity which is not damaged in an artificial gastric juice with time. |