| 摘要 |
The invention comprises compounds of the formula <FORM:0995951/C2/1> wherein B and D each represent hydrogen, C1- 4 alkyl or R1CO, R1 representing C1- 4 alkyl, and their non-toxic, acid-addition salts, and a process for their production by reacting a glyoxal derivative of the formula <FORM:0995951/C2/2> wherein A represents CHO or CH(OR)2, R representing hydrogen, C1-4 alkyl, benzyl or R1CO, R1 representing C1-4 alkyl, with an aminoguanidine or one of its salts of the formula <FORM:0995951/C2/3> wherein B1 and D1 each represent hydrogen or C1-4 alkyl, with heating in an inert solvent, e.g. water or a C1-4 alkyl alcohol, and, if desired, when at least one of B1 and D1 stands for hydrogen, acylating the resulting compound. The condensation reaction is preferably carried out at pH 7.5 to 9.0. The compounds are stated to have antibacterial activity.ALSO:Pharmaceutical compositions having anti-bacterial activity comprise a compound of the formula <FORM:0995951/A5-A6/1> wherein B and D each represent hydrogen, C1-4 alkyl or R1CO, R1 representing C1-4 alkyl, or a non-toxic, acid-addition salt thereof, and a carrier. The compositions may be formulated, for example, as tablets, capsules, ampoules, ointments, tinctures or solutions, or may be in the form of foodstuffs. In Example 7, a feed mixture is prepared comprising 3-(N-methyl)-amino - 6 - (51 - nitro - 21 - furyl) - 1,2,4 - triazine, Vitamins A, B12, D3, E and K3, choline, chloride, riboflavin, pantothenic acid, niacin, methionine and bacitracin. |
