E.COLI HEAT STABLE ENTEROTOXIN DERIVATIVES,PREPARATION THEREOF AND ANTIDIARRHEAL COMPOSITIONS COMPRISING THEM

摘要

E. coli heat stable (ST) enterotoxin derivatives are prepared by reaction of E. coli ST enterotoxin with crosslinking agents for proteins. The so-obtained crosslinked ST enterotoxins show immunogenic activity; they are valuable prophylactic agent for protecting man and animals against diarrheal disease provoked by E. coli enterotoxin and they may be formulated into compositions for intramuscular, subcutaneous or oral administration.