beta,beta,beta-Trihalo-alpha-hydroxyethyl-substituted 2-aroylpyrrole derivatives

摘要

beta , beta , beta -Trihalo- alpha -hydroxyethyl-substituted 2-aroylpyrrole derivatives have the formula I. In this formula: R denotes a lower alkyl group; R' denotes hydrogen or methyl; Y denotes hydrogen, a lower alkyl group, a lower alkoxy group or a halogen atom; and X denotes chlorine or bromine. The compounds, which can be obtained in good yield, are important precursors for the preparation of anti-inflammatory 1-methyl-5-aroyl- pyrrole acetic acids. <IMAGE>