| 摘要 |
NEW MATERIAL:Cyclic peptide RA-III and IV-A. RA-111-A has the following properties. Namely. Molecular weight 828 (by EI-MS). Properties colorless powder. Melting point 213-215 deg.C. Specific rotatory power [alpha]<24>D: -185 degree (C= 0.23 in CHCl3). Ultraviolet absorption spectrum lambdaE<t>OHmaxnm(epsilon);<277(3200)>283.5(2700). Infrared absorption spectrum nuKB<r>maxcm<-1>: 3390, 2950, 1745, 1623, 1582, 1050, 1442, and 1410. Nuclear magnetic resonance spectrum (CDCl3)delta(ppm): 2.08, 2.70, 2.98, 3.14, 3.80, 3.94 (all 3H, S). Containing D- and L-alanine, N-methyl-4-methoxy- L-phenylalanine as amino acids, and a number of amino acid is 6. USE:A strong antitumor agent for malignant tumor. PROCESS:For example, RA-III and VI extracted from Rubiae radix is acetylated, an acetyl group is linked to a liberated hydroxyl group, to give RA-III and VI-A. |
