| 摘要 |
NEW MATERIAL:A compound shown by the formula I (X is OH which may be protected, or amino). EXAMPLE:N-[(1S, 2S)-(2, S/3, 4)-4-Amino-2, 3-dihydroxy-6-methylcyclohexyl]valiolamine. USE:An alpha-glucosidase inhibitor. Useful for preventing various kinds of diseases caused by hyperglycemia and hyperglycoplasmia, such as corpulence, adiposis, arteriosclerosis, diabetes, prediabetes, and diseases caused by saccharometabolism through microorganisms in the oral cavity, such as decayed tooth, etc. PROCESS:Valiolamine shown by the formula II is reacted with a cyclic ketone shown by the formula III (Z' is protected amino) in a solvent such as water, methanol, ethanol, etc. to give a Schiff base, which is reduced to give a compound shown by the formula IV (Z'' is the same as Z'). This compound is deprotected, if necessary. |
