| 摘要 |
PURPOSE:To obtain swainsonine useful as an immuno-regulating agent, by culturing a bacterial strain belonging to Metarhizium genus and capable of producing swainsonine (including novel bacterial strain), and separating the objective compound from the cultured product. CONSTITUTION:A swainsonine-producing strain belonging to Metarhizium genus [including novel Metarhizium anisopliae F-3622 (FERM-P 7193) and sp F-3600 (FERM-P 7192)] is cultured in a nutrient liquid medium preferably under aerobic condition. Swainsonine of formula [chemical name; (1S, 2R, 8R, 8aR)-1,2,8-trihydroxyoctahydroindolidine] is separated from the cultured product by conventional means. It has been found that the known compound of formula and its salt have immuno-regulating activity. Accordingly, the compound of formula is useful as an immuno-regulating agent for the remedy of immuno-insufficiency (e.g. tumor, infectious diseases, autoimmune diseases, etc.). |
