| 摘要 |
A process for the preparation of N-phosphonomethylglycine characterised in that it comprises:… (a) reacting formaldehyde with formamide at a pH of between 9 and 10 to form N-(hydroxymethyl)formamide;… (b) reacting N-(hydroxymethyl) formamide with triethyl phosphite to form diethyl, N-(formyl)aminomethylphosphonate;… (c) reacting diethyl, N-(formyl)aminomethylphosphonate with methylchloroacetate to form N-(diethylphosphonomethyl), N-(formyl)glycinemethyl ester; and… (d) reacting N-(diethylphosphonomethyl) N-(formyl)-glycine methyl ester with a hydrolyzing agent to form N-phosphonomethylglycine is disclosed. …<??>A process for the preparation of N-phosphonomethylglycine characterised in that it comprises:… (a) reacting an aminomethylphosphonate corresponding to the following general formula: ……R-NH-CH2-@-(OR min )2… wherein R represents formyl, acetyl, methoxycarbonyl, phenyloxycarvonyl or benzyl; and R min represents methyl, ethyl, propyl, butyl, pentyl or hexyl; with methylchloroacetate in the presence of an organic solvent and a proton-extracing base to form as an intermediate product, N-(dialkylphosphonomethyl), N-(substituted)glycinemethyl ester; and… (b) reacting the N-(dialkylphosphonomethyl), N-(substituted)glycinemethyl ester with a hydrolyzing agent to cause formation of N-phosphonomethylglycine is also disclosed. …<??>Thus, the production of a valuable herbicide is improved. |
