Packing materials for chromatographic use and their employment in analysing enantiomeric mixtures.

摘要

A packing material for chromatographic use comprises an inorganic carrier having hydroxyl groups at the surface thereof onto which are grafted an organosilane being a urea derivative obtained by reacting an optically active isocyanate with an aminoalkylsilane, an N-carbamoyl amino acid derivative obtained by reacting an optically active amino acid carbamoylated by isocyanate with an aminoalkylsilane or an O-carbamoyl hydroxy acid derivative obtained by reacting an optically active hydroxy acid carbamoylated by isocyanate with an aminoalkylsilane. This packing material is useful in the analysis by liquid chromatography of an enantiomeric mixture of a compound having an -OH group, a -CONH- group, a -CON- group, a -COO- group, an -NHCOO- group, an -NHCONH- group or an -NHCON- group bonded to an asymmetric carbon atom thereof.